ABSTRACT
COVID-19, as a public health emergency, poses a major challenge to the economic and social development of numerous countries, impacting not only the psychology and behavior of residents at the individual level, but also the stability of society at the societal level, typified by the increased difficulty of smooth economic operation due to residents' irrational consumption behavior. In the present study, we have drawn on the psychological stimuli-organism-response (SOR) and mediating effect theories to explore the causes of irrational consumption behavior. Finally, based on the actual situation in the questionnaire survey, we propose the system for assessing the effectiveness of the government's response to the epidemic and measures under the influence of irrational consumption. In the results of our study, we found that the positive and negative irrational consumption adjustment coefficients of the government under the influence of its inherent image were 6.72% and 17.64%, respectively;the government intervention indices under the positive and negative perceptions output according to QFD theory were 0.14 and 0.02, respectively;and the positive and negative measure effectiveness indices of the government response programs were 2.28 and 2.10, respectively. Thus, through our study, we concluded that residents' positive perception of government image would reduce the occurrence of irrational consumption behavior, while the improvement of irrational consumption behavior by perfect psychological services under residents' negative perception of government image is more obvious. On the basis of summarizing the experience of this COVID-19, this study can serve the prediction and regulation of residents' irrational consumption behavior under the government response to public health emergencies, and also enrich the research literature on irrational consumption behavior in related consumption behavior studies, and more importantly, provide theoretical and empirical support for similar academic cases in the international community. [ FROM AUTHOR]
ABSTRACT
Despite global vaccination efforts, COVID-19 breakthrough infections caused by variant virus continue to occur frequently, long-term sequelae of COVID-19 infection like neuronal dysfunction emerge as a noteworthy issue. Neuroimmune disorder induced by Inflammatory factor storm was considered as a possible reason, however, little was known about the functional factors affecting neuroimmune response to this virus. Here, using medial prefrontal cortex single cell data of COVID-19 patients, expression pattern analysis indicated that some immune-related pathway genes expressed specifically, including genes associated with T cell receptor, TNF signaling in microglia and Cytokine-cytokine receptor interaction and HIF-1 signaling pathway genes in astrocytes. Besides the well-known immune-related cell type microglia, we also observed immune-related factors like IL17D, TNFRSF1A and TLR4 expressed in Astrocytes. Based on the ligand-receptor relationship of immune-related factors, crosstalk landscape among cell clusters were analyzed. The findings indicated that astrocytes collaborated with microglia and affect excitatory neurons, participating in the process of immune response and neuronal dysfunction. Moreover, subset of astrocytes specific immune factors (hinged neuroimmune genes) were proved to correlate with Covid-19 infection and ventilator-associated pneumonia using multi-tissue RNA-seq and scRNA-seq data. Function characterization clarified that hinged neuroimmune genes were involved in activation of inflammation and hypoxia signaling pathways, which could lead to hyper-responses related neurological sequelae. Finally, a risk model was constructed and testified in RNA-seq and scRNA data of peripheral blood.